Paul Gissen is a Clinical Professor of Paediatric Metabolic Medicine at the UCL Great Ormond Street Institute of Child Health, a position he has held since 2013, and an Honorary Consultant at Great Ormond Street Hospital for Children (GOSH). He obtained his medical degree from the University of Glasgow in 1995 and completed his paediatric training at Manchester, Sheffield, and Birmingham Children’s Hospitals, specialising in inherited metabolic disorders.

During his PhD at the University of Birmingham, Paul contributed to the identification of genetic causes of several inherited paediatric diseases. He now leads a translational research group focused on developing experimental therapies for rare paediatric conditions, taking discoveries from preclinical models through to first-in-human studies. Since 2021, he has led the Gene, Stem and Cellular Therapies Theme within the GOSH–UCL Institute of Child Health Biomedical Research Centre, and in 2026 he was appointed Director-Designate of the Centre.